Here are some one liners...
Pope Innocent is a Little Too Innocent -- The Rodrigo Borgia cannot be Pope so he supports an easily manipulable man as Pope. This Pope will preside over the rounding up of witches, heretics and the Jews. He is also considered the Pope of the New World, yet he died a few days before Columbus left on his voyage.
The People of the Reformation and the 'Pious Ones' -- Several people of the Reformation are born this year, but mostly I talk about religious training of the time called the Trivium and compare it to rote Jewish learning practices of the time and today.
Pope Innocent is a Little Too InnocentPope Sixtus the 4th dies at the age of 70. Rodrigo Borgia wants to be Pope but his rival, Giuliano della Rovere, controls enough votes to block him. They decide to pool their votes to elect a non-entity who takes the name of Pope Innocent the 8th. The Pope is a Genoan, so he meets the main qualification... he is not a Venetian. (The Venetians were in bad odor at the time.) As the new Pope starts handing out the benefits of his office, Rodrigo does well, but Giuliano has more influence and will goad the Pope into joining a minor war to support the barons of Naples. It may not seem like much, but that little war will be the first small stone ahead of an avalanche. That avalanche won't hit Italy until the 1500s. In the meantime, Pope Innocent has work to do.    
The People of the Reformation and the 'Pious Ones'Several key people of the Protestant Reformation and the resistance to that Reformation are born this year.
1. Jón Arason will grow up to become the Roman Catholic bishop for Iceland. He will be executed for his efforts to oppose the Reformation.
2. George Spalatin will become an ordained priest and an important advisor to Reverend Martin Luther.
3. Ulrich Zwingli will become a pastor in Zurich preaching reform of the Catholic Church and criticizing the system of Swiss Mercenaries which not only hired themselves out to various nations but also dedicated themselves to the defense of the Pope's physical person... which the Swiss Guard continue to do into the modern day.