Here are some one liners...
Smallpox Variolation is Made Illegal -- You know when they take a sample of live smallpox and shove it into an open wound. THAT is now illegal.
The Damascus Affair -- Antisemitism in Syria outrages the world and unites the Jews as never before.
Natchez Landing is Missing -- The 2nd deadliest tornado in US history. I talk about my own experience with a tornado.
In Other News -- The penny postage stamp, a hoax, and the inventor of the portable machine gun is born.
Smallpox Variolation is Made IllegalThis is NOT vaccination per se. We are talking about "variolation" where you find a person who already has smallpox. You rub the pustules to get some infected material, and then rub that material into the open wound of an uninfected person. The UK has made THAT illegal. The safer form of inoculation is the COW POX vaccine. ("Vacca" is Latin for "cow" which is why it is called a VACCINATION!) It was discovered in the 1770s after it was noticed that milk maids (the gals who milk the cows) had unusually pretty skin. Most people ended up with scars on their face if they lived through smallpox, but milk maids had caught the cow pox disease which was similar to small pox and it gave them immunity. The vaccine has been available for years to aristocrats, but it hasn't caught on with the masses. That is probably why it is being offered for free to encourage more people to use the vaccine rather than the more dangerous method described above. By 1853, the smallpox vaccination of children will be made compulsory (if health permits) and each physician will be required to certify to the government that said child was vaccinated.  
The Damascus AffairFor the first time the US Jewish community speaks up in international affairs.... and it works. It begins in Syria. Christians and Jews have been competing for business within the Muslim community, but when a French Catholic priest and his servant go missing, the Christian community accuses the Jews of kidnapping them for a strange blood ritual. The Muslim officials play along with this canard for a while, arresting a Jewish barber and torturing him until he implicates himself and several other Jews. One Jew escapes torture by converting to Islam. (It is not made clear why a conversion to Islam exonerates one from murder charges.) Other Jews die during questioning or pass away in prison. The rest hold up under the torture. The world is outraged. ("The world" is defined as Austria, the UK and the USA which is a fair chunk of the world.) Jews in the United States beg President Van Buren to protest this injustice. He does so. Negotiators from several countries go to the Ottoman Sultan to appeal this injustice. The Sultan agrees that the accusations of a blood ritual are absurd. The nine Jews who are still alive are declared innocent and released. The Damascus Affair will have far-reaching implications in terms of the power of international public opinion and the unification of the Jews.  
Natchez Landing is MissingIt is an hour after noon with the sound of thunder turning into a roar as black billowing clouds overcome the people at Natchez Landing along the Mississippi. It's a twister! Trees are stripped of their leaves. Buildings are flattened. Timbers, bricks, and entire walls fly though the air, "as if thrown from a mighty catapult". Within 5 minutes 48 people lay dead, but the worst of the disaster is taking place on the Mississippi River itself. The river ferry has sunk with all hands. Boats are picked up and flung onto the land with the people still hanging on. A chunk of a steamboat will be found 30 miles away. Mrs. Alexander will be found broken and bleeding but still alive. Her two children will lay dead in her arms. The tornado will hit Vidalia on the Louisiana side next. When it is all over, the death toll will be 317. That will make it the second deadliest tornado in US history. The deadliest will come in 1925 when the Great Tri-State Tornado will kill 695 people.   
In Other News
- The world's 1st penny postage stamp is sold. A letter can be sent anywhere in the UK for 1 penny. This makes the Royal Mail more easily available to the masses. 
- The Fortas Collection of rare books is up for auction. It's a hoax! The catalog of fake books that was prepared for a non-existent auction is worth a pretty penny now. 
- Hiram Maxim is born in Maine. The Maxim Gun will be the first portable, fully automatic machine gun. He will also invent the mousetrap and the curling iron. Which of these will be the most important contribution? You be the judge.