Here are some one liners...
The Portuguese Reach the REAL India -- Vasco makes the run from Liston to India in a little less than 11 months. His voyage will overturn the old thinking about how the trading routes to Europe work.
The First Italian War Ends with a Crack -- The King of France knocks his noggin on a door lintel in his palace ending the war and placing his cousin on the throne. The new king will then accuse his wife of being deformed in order to get an annulment and marry Anne of Brittany.
Christopher Columbus's 3rd Voyage Goes Badly -- Columbus touches the coast of South America but he turns ill and heads for Hispaniola. The colony is in rebellion and he puts it down ruthlessly.