Here are some one liners...
No Africans, No Jews, and No Orthodox Christians -- Queen Isabella does not want to fill up the New World with non-Christian castoffs so she orders a stop to African slaves, Jews and Orthodox Christian converts. Indians are pure souls and must be offered Christianity. But real money is at stake here so her ideals will remain just that... ideals.
The Pope Orders a Book... Burning -- The Gutenberg press has put pressure on the Church and the Church is pushing back. The Church is going to lose this one but they are not going to stop trying. And... a minor Martin Luther update included.
Rio de Janeiro (January's River) is not a River -- The Portuguese head west to China and hit Brazil. Now you know why Brazilians speak Portuguese.